One Pot Synthesis of Novel 4-[(5-Aryl-1,3,4-thiadiazol-2-ylamino)methyl]phenol Derivatives
نویسندگان
چکیده
منابع مشابه
An efficient one-pot synthesis of dimethyl 1-(Aryl)-5-cyano-4-(cyclohexylamino)-1,2,5,6-tetrahydro-6-oxopyridine-2,3-dicarboxylate derivatives
Abstract: The reactive 1:1 intermediate produced in the reaction between cyclohexyl isocyanide and electron- deficient acetylenic esters or dimethyl acetylene dicarboxylate was trapped by 2-cyano-N-(Aryl) acetamides to provides highly functionalized oxopyridine (potential synthetic and pharmaceutical interest ) in acetonitrile under mild reaction conditions at ambient temperature after 24 h ...
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The green synthesis of 5-(4-aminophenyl)-4-aryl-4H-1,2,4-triazole-3-thiol was achieved in four steps, In first step, 4-amino benzoic acid refluxed in ethanol along with catalyst Conc. Sulphuric acid to produce ethyl-4-amino benzoate I. Further compound I refluxed with hydrazine hydrate in ethanol to produce 4-amino benzohydrazide II. Compound II refluxed in ethanolic potassium hydroxide with ca...
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Reaction of 3,4,5,6-tetrahydro-2-pyrimidinethiol, prepared by cyclocondensation reaction of 1,3-diamino propane 1 and carbon disulfide, with ethyl chloroacetate and substituted aromatic aldehydes in the presence of sodium acetate and acetic acid gave 2-[(Z)-1-(aryl)]-6,7-dihydro-2H-isothiazolo[2,3-a]pyrimidine-3(5H)-one derivatives 3(a-j) in good yields. 1H-NMR spectroscopy, and elemental analy...
متن کاملDesign, synthesis and antimicrobial evaluation of novel 2-aryl-thiazolidin-4-one derivatives
Novel 2-arylthiazolidin-4-one derivatives (8a-q and 11) have been synthesized in good-to-excellent yields (70-96%) by one-pot three-component condensation-cyclization reaction of aromatic or aliphatic primary amines, aromatic aldehydes, and thioglycolic acid in polypropylene glycol at 110°C temperature. The in vitro antimicrobial activity of the synthesized 2-arylthiazolidin-4-ones was investig...
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2012
ISSN: 0253-2786
DOI: 10.6023/cjoc1110131